Erasmus : Behaviour, memory and work performance often deteriorate in pregnant women. Common findings on testing include high white cell counts, protein loss, hypogammaglobulinemia and low antibody levels. Pregnancy can severely affect immune function in many women, with serious long term injury.

This web page discusses the proposed role of Paill Spectrum in pregnancy related illnesses. Paill Spectrum may play a role in conditions such as development, delay, neonatal brain swelling, epilepsy, mood disorder and memory problems. The ability to fight infection may be compromised.

Kinkajou : Everyone Laughs at the stupid things that pregnant women do. They forget things. They seem to be somewhere else (like in another world) and drive into things that should be obvious to anyone with half a brain.
Everyone feels sorry for them and maybe they should be.
But maybe the problem is not just their hormones.

DR Xxxxx : A severe version of this common problem (pregnant brain), begins with some simple basic blood test changes of apparently no significance. A small number of women develop white cell count elevations in mid to late pregnancy and no explanation can be found. The changes are often specific to the time of the pregnancy only. The white cell count changes (elevations), almost always disappear following the delivery of the baby. The body function returns to normal after the pregnancy is over. No doctor can find anything wrong with the women, no one worries about it, and no one does anything about it.

In the Paill Spectrum model, Paill Spectrum does not normally “directly” change white cell counts in pregnant women. However this page discusses the new Paill Spectrum model of pregnancy related illnesses.
High white cell counts, protein loss and low antibody levels can change many aspects of health. Paill Spectrum initiates changes in how a pregnant woman's body works.

Paill Spectrum Model In Pregnancy
"A Theoretical Discussion"

Kinkajou: So What could be going on in Pregnancy, to cause white cell counts to rise?

Parasitic infections may be a cause of the blood test abnormalities such as elevations of white cell counts. General bacterial infections also increase white cell counts. Usually a checkup by a doctor reveals no obvious cause for the finding of raised white cell counts. The pregnant woman is quite well and has no obvious illness or infection or problem anywhere to be found.

The patient has a number of assessments and tests done, by her doctor.

Usually it is found that the Pap smear is normal,
The vaginal swabs are normal (including tests for atypical organisms),
There are no skin lesions,
There are no chest problems or respiratory problems (no cough or cold symptoms),
No throat infection,
The stomach is normal, (no vomiting or diarrhoea),
No urinary problems

Often cervicitis (an infection of the cervix of the woman's uterus, the uterus being the organ that holds the baby) is blamed, as it appears to be the only likely / possible site of inflammation, that can be inferred (guessed) from the medical assessment. There are usually no symptoms that can be attributed to local infections in the body. The patients cervix seems perhaps to be a little irritated, but often these are just changes typical of pregnancy.

Obviously, some "event" must be occurring in pregnancy, which is causing the observed blood (white cell) change. There must be some pathological process occurring in these women causing the medical abnormalities noticed. This pathological process must be unique to the pregnancy state. Back To Pregnancy Top

DR Xxxxx : Paill Spectrum Model In Pregnancy : the Process

So What could be Happening in Pregnancy?

In pregnant women after the first thirteen weeks of pregnancy (called by doctors the first trimester), blood vessels open up. Blood is short circuited through the placenta which has a low resistance to flow. The blood ends up being pumped around the body faster and faster to meet the metabolic demands of the baby and the mother.

In a small number of patients, increased blood flow through the kidneys, appears to trigger increased protein loss during the late first trimester of pregnancy. may be involved by triggering renal damage at a microscopic level, most often in women with initially normal blood pressure. (see Blood Pressure). These women develop hypogammaglobulinemia (i.e. low blood antibody levels. This is easily measured by IgG IgA IgM quantitation assays).

Paill Spectrum Paill Spectrum

Low antibody levels result in a drop in the body's ability to fight infection. Germs are able to evade the body's defences in many places all over the body: the gums, the skin, the intestinal lining and in the vagina. To cope with this immune resistance problem, the body elevates the numbers of white cells in the blood to help fight all these germs in their normal homes and to stop these germs from invading the body.

Hypogammaglobulinemia. in a Paill Spectrum pregnancy per se, is not a serious event. However it allows serious events to begin to unfold.

DR Xxxxx : Illness events would typically develop most severely in women with the most borderline health status at the beginning of the pregnancy. Women with existing wheat allergy or nutritional deficiencies are particularly at risk. Nutritional deficiency is often associated with lower socioeconomic class, so it is probable that illness is worse in these women. Sadly, they can least afford to lose anything and end up losing the most. Women at most risk of having their medical status deteriorate are of course those who have the worst health status to begin with. Existing depression, anxiety or panic disorder, strange ideas and weight problems are likely to worsen as a result. Memory problems may occur. Blood pressure changes are predicted to be typical by the Paill Spectrum model of disease and will develop more commonly as the pregnancy comes closer to delivery.

In the PaillSpectrum model, problems also occur in the baby. Hypogammaglobulinemia. allows accelerated disease spread with a few unlucky women developing colonisation . As Paill Spectrum is a very slow growing infective organism, there is considerable bad luck involved in the combination of events and the timing of events, namely:

Hypogammaglobulinemia.
Third wave maternal infection
Foetal colonisation across the placenta: Back To Pregnancy Top

In the Paill Spectrum model, it is only when the woman is pregnant at just the right stage of pregnancy and has the PaillSpectrum syndrome at just the right phase of the baby's growth, that problems may occur.
There is a very small window of opportunity for significant problems to develop.

DR Xxxxx : Prediction Of the PaillSpectrum Model in Pregnant Women:

Consequently, damage syndromes are very rare but would be expected to be extremely severe in the unlucky few affected babies. In the PaillSpectrum model, babies or neonates as doctors call them have very poor immune systems, and it is likely that the Paill Spectrum Syndrome would have a very rapid growth phase in a patient with poor cell mediated or lymphocyte mediated (a type of white cell) immunity. The model would predict that some children could be predicted to have severe deficits evident at birth.

Some of the children soon after birth occasionally have obvious Paill Spectrum infection with sleep disturbance and sweaty hands in the early post natal period, but with no evidence of damage. The PaillSpectrum Condition just missed the window of opportunity for maximum injury, arriving in the baby a little too late to do any real damage. These symptoms would be expected to respond reasonably well to standard Paill Spectrum therapies, in the PaillSpectrum model. Some of the mothers develop suspicious post partum events such as extreme blood pressure variability or general extreme illness, especially in the post-delivery period. Back To Pregnancy Top

The Immunoglobulin assays are an unreliable determinant of “neonatal” infection, as it typically takes years for the immune response to the slowly progressive Paill Spectrum infection, to create sufficient "antigen load" to elevate the immunoglobulins, especially in the neonatal group. Neonates or babies typically have deficient immune responses and immune memory, so disease markers would have substantially different reference ranges to the adult population. In short, it is almost impossible to diagnose Paill Spectrum in babies using the traditional PaillSpectrum criteria (such as blood tests), that are useful in adults. Even the symptoms of illness are rare. Babies don't really do much so it likely be years before clinical evidence (symptoms and signs) of a Paill Spectrum Illnesses is found.

Erasmus : It is critical to treat people with effective therapy, not just symptomatic antiepileptic medication, or drugs. Medicine for “symptoms” does not change the progress of the disease. However, even simple Nutritional therapies can be very effective in controlling Paill Spectrum infection. Nutritional therapies can be erratic in their effectiveness, so antibiotics will usually need to maximise patient safety.

Applying nutritional therapy to babies is also very difficult. Babies are fed formula so their dietary needs have been extensively researched. They routinely do not eat the foods that cause problems in adults. So nutritional manipulation probably has limited upside in babies. Dietary manipulation, which is a basic necessity in treating PaillSpectrum in adults, is unlikely to show clinical or blood test benefit in babies, simply because most babies in our society are nourished very well indeed.

Applying nutritional therapies to toddlers is quite possible and quite useful. Diet and nutrition do make a difference, according to the PaillSpectrum model. Back To Pregnancy Top

Running Toddler, post pregnancy

DR Xxxxx : Prognosis for Neonates with Paill Spectrum Infection:

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There is no magic cure for children born from Paill Spectrum infected mothers. Without treatment however, the PaillSpectrum model predicts that the Paill Spectrum condition continues to progress. Some children may be badly affected. Other children may show minimal symptoms. Children, especially the youngest children, don't really do much that is assessable except "coarsely". They also are most likely to have the shortest PaillSpectrum clinical histories, and therefore the least symptoms. There is consequently little scope for using symptoms for diagnosis, the younger the child is. Sweaty hands and excessive sleep are common symptoms in children with early stage Paill Spectrum infection. Back To Pregnancy Top

DR Xxxxx : Predictions of The PaillSpectrum Model in Post-Pregnancy:
Typical Events May Include:

Episodes of severe brain swelling, not associated with birth trauma or other physical injury (likely causative factors). This severe reaction is very rare and demands a unique set of difficult circumstances to allow it to develop to this extent. (Similar to the scenario above). In the PaillSpectrum model, permanent injuries and deficits are likely as a result.
Injury patterns, as above, without evidence of cerebral swelling.
Epilepsy:
- Pattern 1: progressive deterioration
- Pattern 2: Stabilizing then disappearing over years as the child grows out of childhood
- Pattern 3: Fits occurring in the context of “patches” of high temperatures or fevers

Developmental Delay (mild or severe), with some resolution of deficits in cases with the best Paill Spectrum risk profiles. The lowest PaillSpectrum risk profile is predicted to occur by the model in patients with optimum nutrition and no clinically significant wheat allergy, (defined in the model as IgG gliadin and IgA gliadin less than 20-25% of the reference range as calibrated for endoscopically proven Coeliac Disease).
Memory Issues Back To Pregnancy Top
Behavioural Disturbances; See Keywords Page
Childhood depression or mood disorder
Childhood neural cross-linking does occur:
The model predicts that this is a rare event in a growing brain. The symptom presentation is often unrecognised by many adult carers due to the simplicity and innocence of the symptoms.
For example, a child may have trouble sleeping and complain to their parents that birds talking are keeping them (the child) awake. The adults can hear no bird noise, but often give the child the benefit of a doubt, at least on the first occasion that the symptom presents.
.

These events would be expected to be more severe initially in affected patients but over time the incidence and prevalence data would regress towards the norm for the population, to a variable extent.

DR Xxxxx : Long Term Predictions for Neonates
in the Paill Spectrum Model

There is a classical IgM and IgG immune response evident over three months would be expected. The blood test results are unlikely to meet adult threshold criteria for a diagnosis confirmation.

Symptoms may return in some patients in three to nine months if underlaying nutritional risk factors remain unchanged.

Other more typical PaillSpectrum syndromes are more likely to develop, the worse the risk factors likely the worse the clinical syndrome.

Disclaimer on the Paill Spectrum Model

The conclusions arising from the Paill Spectrum model of disease as pioneered by Dr. Xxxxx, implies that the causation of many medical conditions varies substantially from current medical thinking. Until research and further assessment of these concepts validates the concepts proposed, you must make your own mind up about what treatment regime you follow. Paill Spectrum therapy gives distinct identifiable and measurable feedback to both patients and their treating doctors at every step of a therapy cycle. Symptoms improve and these are usually obvious to patients, their carers and their doctors, usually starting from within two weeks of initiation of the treatment cycle. Back To Pregnancy Top

Dr. Xxxxx sees a small number of children in the neonatal period and has experienced only erratic follow up of these patients. While the Paill Spectrum model would indicate that events would unfold as in this article, there is not a lot of "depth" of clinical cases or experience to conclude that severe damage events occur in the neonatal period. The article presents many theoretical aspects of the PaillSpectrum model, for children of younger age ranges.

Back To Pregnancy Top

Disclaimer

title
Erasmus : Pregnancy Treatment New

description content
Discusses the new Paill Spectrum model pregnancy related illnesses : high white cell counts, protein loss and low antibody levels can change many aspects of illness.

keywords content
pregnancy, development, delay, low immunity, low antibodies, raised White cell count, neonate, brain swelling, epilepsy, mood disorder, memory problems, white cell count, hypogammaglobulinemia, protein loss, low antibody level, blood antibody level, fight infection, first trimester, immune response, natal, childhood

Paill Spectrum Model In Pregnancy "A Theoretical Discussion"

DR Xxxxx : Paill Spectrum Model In Pregnancy : the Process So What could be Happening in Pregnancy?