Web Avatars: Erasmus and Kinkajou 
Web Avatars: Erasmus and Kinkajou Auto-immune Disease
DR Xxxxx: The auto-immune diseases are a diverse group of medical conditions affecting many different tissues and organs throughout the body.
They are loosely divided into two types: organ specific and multi-organ types. Organ specific disease include conditions such as: Grave's Disease,Hashimoto's disease, Diabetes, or (classical) Addison's Syndrome. Multi-organ autoimmune diseases include conditions such as: SLE (Systemic Lupus), other Connective Tissues Diseases or Rheumatoid Arthritis . All these conditions are characterised by the presence of unique antibodies that target specific body parts or tissues
e.g.
Examples or Multi-organ Immune Diseases Include:
The most common disorders in primary medical practice are the Collagen vascular diseases or the Connective Tissue diseases. Rheumatoid arthritis and its variants are perhaps the most common of these auto-immune disorders in current medical practice. They often have arthritis as a symptom.
Examples of organ specific immune diseases include
There is a question as to whether there is a "true" distinction between organ specific and multi-organ immune diseases. Alternately, does this simply reflect that the affected “single” tissues in multi-organ immune disease are just present in multiple organs, so their clinical effects are seen, in multiple organs?
Erasmus : The concept of autoimmunity is a rather weird one. One would expect that the development of anti- self antibodies would be a process that is substantially proscribed by evolution as being not consistent with the survival of a species.
DR Xxxxx : The Paill Spectrum model takes a different interpretation on the development of auto-immunity. Auto-immunity will often simply be "IMMUNITY" where we currently have no understanding of what the triggering or activating antigens may be. Especially, anti-nuclear antibodies will rise and fall six months after an immune event has occurred. The type of ENA is important as it may help to point to the likely antigen source for antibody formation.
Paill Spectrum theory says that auto-immunity may in fact exist, but most of what we are dealing with is simply immunity or disordered immunity. Our understanding of immune activation in the intestine is not sufficient to work out what the trigger factor may be in inflammatory bowel diseases. Most Irritable bowel disease however is due to wheat or gluten / allergy or sensitivity. There are substantial immune effects resulting from exposure to gluten in a genetically susceptible individual.
Dr Axxxx : CENSORED ref AX4001 by order of “Frobisher” authorised by “The Commandant”
DR Xxxxx : Paradox of methotrexate or steroid therapy : It is likely that a number of our immune suppressant drugs do not function as immune suppressants at all primarily but as control agents for unrecognised illnesses. e.g. Methotrexate as an antifolate agent controlling organism growth e.g. Mercaptopurine as an antinucleotide agent for Noël Fragment disease processes. This type of information may predicate a new dose protocol method. Continuous therapy may not be indicated in favour of intermittent combination therapies.
DR Xxxxx : Mechanisms for the development of autoimmune antibodies may include:
It is likely that a number of our immune suppressant drugs do not function as immune suppressants at all primarily but as control agents for unrecognised illnesses. e.g. Methotrexate as an antifolate agent controlling organism growth e.g. Mercaptopurine as an antinucleotide agent for Noël Fragment disease processes.
DR Xxxxx : Current trends in medical practice are drifting towards the increased use of immunosuppressive medications such as Methotrexate or 6-mercaptopurine. These are regarded as cell toxic immune suppressive medications. By suppressing the immune system, inflammation is reduced and the patient feels better. These medications are very potent in suppressing cell growth. Some patients even on small doses may have tissue healing impaired to such an extent that they have difficulty in healing even small superficial scratches.
The treatment of these disorders is a difficult area to understand the long term consequences of clinical decisions because of the very long lag times between action and effect, clinical variability amongst patients and the complex clinical conditions of the patients involved. (They are often elderly and have multiple medical problems). Back to Autoimmune top
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Kinkajou: Dr. Xxxxx observes that many patients who are started on immunosuppressive medication actually respond very well initially clinically. Inflammation is reduced and pain levels drop.
Very often in 1-2 years, the clinical condition worsens, and the patient needs to have their doses of immunosuppressive medications increased. This usually works well and the condition again comes under control with relief for the patient. This happens again in 1-2 years.
This cycle of doses increases is played out over decades, with quite significant weekly doses of immunosuppressives being used eventually in most patients. The patients are told that the condition must be worsening.
Where immunosuppressives are not used, the patients do not seem to undergo the same “clinical worsening.”
Related Topics in this Series:
Erasmus: This web page introduces a new theory (Paill Spectrum) to explain autoimmune diseases. The Paill Spectrum model suggests that other symptoms such as chronic fatigue, sweaty hands, dizziness, or loss of balance, aches and pains may be associated. Associated symptoms may also be Fibromyalgia, Arthritis, Sore Hands.
Associated Conditions may include cirrhosis.
Autoimmune diseases include: Hashimotos disease, Graves disease, Insulin dependent diabetes, NIDDM type 1 with insulin or islet cell antibodies,, Primary Biliary Cirrhosis, Addison's disease, Rheumatoid Arthritis, Connective Tissue Disease, SLE or Lupus, , connective tissue disease, lupus, collagen, disease or Myasthenia Gravis. The lag time in immune effects is particularly well demonstrated in the onset of diabetes mellitus. Often up to 6 months after the exposure of the patient to Paill immunoactive antibiotics, there is a sudden immune flare, resulting in enhanced destruction of colonised tissue areas, resulting in for example in the case of diabetes a loss of islet cells in the pancreas. The problem starts rapidly and develops suddenly somewhat akin to falling off a cliff.
Dr AXxxxx: CENSORED ref AX4002 by order of “Frobisher” authorised by “The Commandant”
DR Xxxxx: Interesting?
The Paill Spectrum model predicts that Paill Spectrum has a role to play
in at least some auto-immune diseases.
"Noël Fragment" disease as proposed by the Paill Spectrum model would suggest a new novel mechanism for the genesis of a variety of these conditions.
Back to Autoimmune top
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Erasmus: This site discusses the Paill Spectrum theory relevance in explaining autoimmune diseases in conditions such as: Chronic fatigue, Fibromyalgia, Arthritis, Sore Hands, Rheumatoid Arthritis, Connective Tissue Disease and Lupus, (SLE).
There is a Paradox of methotrexate or steroid therapy in chronic treatment of these illnesses: is better really better or just not complaining? The Paill Spectrum model suggest some new alternative approaches to therapy, for patients with worsening disease.
Mechanisms of illness proposed include Noël (Noelle) Fragment Disease, (naked DNA disease).
Dr AXxxxx : So Long Fuckers, Die Soon!
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Erasmus : Autoimmune Diseases: New Treatment Autoimmune therapy currently favours what are called slow acting anti- arthritic or antirheumatoid drugs. (SAARDS). Typical examples are:
methotrexate : an antifolate agent with poor discrimination but with some anti-Lliap actions
6-mercaptopurine: a nucleotide analog drug with CENSORED ref AX4003 by order of “Frobisher” authorised by “The Commandant”
It is likely that a number of our immune suppressant drugs do not function as immune suppressants at all primarily but as control agents for unrecognised illnesses. e.g. Methotrexate as an antifolate agent controlling organism growth e.g. Mercaptopurine as an antinucleotide agent for Noël Fragment disease processes.
The drugs can make you quite ill in short term burst usage, but don't cause anywhere near as many problems in long term usage. This suggests a complex mode of action and probably several modes of action. What the drug does when first given is different to the predominant action in long term usage. Analysing the situation gets complex because the benefit depends on actions at a number of different levels, with the predominant action giving the final answer.
The Paill Spectrum theory suggest that different predominate actions occur at different points along the timescale of the usage of these medicines.
DR Xxxxx : Mechanisms for the development of autoimmune antibodies may include:
Dr AXxxxx: CENSORED ref AX4004 by order of “Frobisher” authorised by “The Commandant”
The Commandant :
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Erasmus : 
Kinkajou: DR Xxxxx : 
Dr AXxxxx 
Goo: :
:
Beethoven and Frobisher 
Beethoven, The Commandant and Frobisher
The Commandant :
Erasmus:
Medical conditions always happen for a reason.
Modern medicine gives no answers and no explanation as to why you may be ill. If there is an explanation, you may often find that the condition just does not get better even though it should. It follows the explanation is wrong.
But there is a cause for illness. To defeat the illness, specific treatments designed to achieve specific purposes are necessary.
DR Xxxxx:
Modern medicines treat nix; they just cover up the symptoms.
Modern medicines treat the symptoms and not the cause.
If you don’t treat your illness with specific effective therapy, you will get progressively sicker.
DR Xxxxx:
Paill Spectrum is a new theory explaining the cause of a number of illness symptoms. It explains symptoms, signs, diagnosis and treatment.
You can improve your health.
You are not mad. You are sick. You can fix the problem.
Knowing the "cause" is everything.
Dr Axxxx : The medical world is an apprenticeship. It guarantees stupid ideas get promulgated. It ensures no one rocks the boat. How can you be right when we all agree any dissenting opinions are wrong.